N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source

doi:10.1021/acsomega.1c01961

GIEC OpenIR

	N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source
	Liu, Jianguo 2,3; Song, Yanpei 1; Wu, Xiang 1; Ma, Longlong1,2
	2021-09-07
发表期刊	ACS OMEGA
ISSN	2470-1343
卷号	6 期号:35 页码:22504-22513
通讯作者	Liu, Jianguo(liujg@ms.giec.ac.cn) ; Ma, Longlong(mall@rns.giec.ac.cn)
摘要	N-methylated amines are essential bioactive compounds and have been widely used in the fine and bulk chemical industries, as well as in pharmaceuticals, agrochemicals, and dyes. Developing green, efficient, and lowcost catalysts for methylation of amines by using efficient and easily accessible methylating reagents is highly desired yet remains a significant challenge. Herein, we report the selective N-dimethylation of different functional amines with different functional aldehydes under easy-to-handle and industrially applicable conditions using carbon-supported Ru nanoparticles (Ru/C) as a heterogeneous catalyst. A broad spectrum of amines could be efficiently converted to their corresponding N,N-dimethyl amines with good compatibility of various functional groups. This method is widely applicable to N-dimethylation of primary amines including aromatic, aliphatic amines with formaldehyde, and synthesis of tertiary amines from primary, secondary amines with different functional aldehydes. The advantage of this newly described method includes operational simplicity, high turnover number, the ready availability of the catalyst, and good functional group compatibility. This Ru/C catalyzed N-dimethylation reaction possibly proceeds through a two-step N-methylation reaction process.
DOI	10.1021/acsomega.1c01961
关键词[WOS]	REDUCTIVE METHYLATION ; AROMATIC-AMINES ; SECONDARY-AMINES ; FORMIC-ACID ; CHEMOSELECTIVE METHYLATION ; COMPLEX BEARING ; NITRO-COMPOUNDS ; METHANOL ; DIOXIDE ; CO2
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFB1501500] ; National Natural Science Foundation of China[51976225] ; DNL Cooperation Fund ; Chinese Academy of Sciences[DNL201916]
WOS研究方向	Chemistry
项目资助者	National Key R&D Program of China ; National Natural Science Foundation of China ; DNL Cooperation Fund ; Chinese Academy of Sciences
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000695518100005
出版者	AMER CHEMICAL SOC
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.giec.ac.cn/handle/344007/33900
专题	中国科学院广州能源研究所
通讯作者	Liu, Jianguo; Ma, Longlong
作者单位	1.Chinese Acad Sci, CAS Key Lab Renewable Energy, Guangdong Prov Key Lab New & Renewable Energy Res, Guangzhou Inst Energy Convers, Guangzhou 510640, Peoples R China 2.Southeast Univ, Sch Energy & Environm, Minist Educ, Key Lab Energy Thermal Convers & Control, Nanjing 210096, Peoples R China 3.Chinese Acad Sci, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jianguo,Song, Yanpei,Wu, Xiang,et al. N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source[J]. ACS OMEGA,2021,6(35):22504-22513.
APA	Liu, Jianguo,Song, Yanpei,Wu, Xiang,&Ma, Longlong.(2021).N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source.ACS OMEGA,6(35),22504-22513.
MLA	Liu, Jianguo,et al."N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source".ACS OMEGA 6.35(2021):22504-22513.