Knowledge Management System Of Guangzhou Institute of Energy Conversion, CAS
N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source | |
Liu, Jianguo2,3; Song, Yanpei1; Wu, Xiang1; Ma, Longlong1,2![]() | |
2021-09-07 | |
Source Publication | ACS OMEGA
![]() |
ISSN | 2470-1343 |
Volume | 6Issue:35Pages:22504-22513 |
Corresponding Author | Liu, Jianguo(liujg@ms.giec.ac.cn) ; Ma, Longlong(mall@rns.giec.ac.cn) |
Abstract | N-methylated amines are essential bioactive compounds and have been widely used in the fine and bulk chemical industries, as well as in pharmaceuticals, agrochemicals, and dyes. Developing green, efficient, and lowcost catalysts for methylation of amines by using efficient and easily accessible methylating reagents is highly desired yet remains a significant challenge. Herein, we report the selective N-dimethylation of different functional amines with different functional aldehydes under easy-to-handle and industrially applicable conditions using carbon-supported Ru nanoparticles (Ru/C) as a heterogeneous catalyst. A broad spectrum of amines could be efficiently converted to their corresponding N,N-dimethyl amines with good compatibility of various functional groups. This method is widely applicable to N-dimethylation of primary amines including aromatic, aliphatic amines with formaldehyde, and synthesis of tertiary amines from primary, secondary amines with different functional aldehydes. The advantage of this newly described method includes operational simplicity, high turnover number, the ready availability of the catalyst, and good functional group compatibility. This Ru/C catalyzed N-dimethylation reaction possibly proceeds through a two-step N-methylation reaction process. |
DOI | 10.1021/acsomega.1c01961 |
WOS Keyword | REDUCTIVE METHYLATION ; AROMATIC-AMINES ; SECONDARY-AMINES ; FORMIC-ACID ; CHEMOSELECTIVE METHYLATION ; COMPLEX BEARING ; NITRO-COMPOUNDS ; METHANOL ; DIOXIDE ; CO2 |
Indexed By | SCI |
Language | 英语 |
Funding Project | National Key R&D Program of China[2018YFB1501500] ; National Natural Science Foundation of China[51976225] ; DNL Cooperation Fund ; Chinese Academy of Sciences[DNL201916] |
WOS Research Area | Chemistry |
Funding Organization | National Key R&D Program of China ; National Natural Science Foundation of China ; DNL Cooperation Fund ; Chinese Academy of Sciences |
WOS Subject | Chemistry, Multidisciplinary |
WOS ID | WOS:000695518100005 |
Publisher | AMER CHEMICAL SOC |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.giec.ac.cn/handle/344007/33900 |
Collection | 中国科学院广州能源研究所 |
Corresponding Author | Liu, Jianguo; Ma, Longlong |
Affiliation | 1.Chinese Acad Sci, CAS Key Lab Renewable Energy, Guangdong Prov Key Lab New & Renewable Energy Res, Guangzhou Inst Energy Convers, Guangzhou 510640, Peoples R China 2.Southeast Univ, Sch Energy & Environm, Minist Educ, Key Lab Energy Thermal Convers & Control, Nanjing 210096, Peoples R China 3.Chinese Acad Sci, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China |
Recommended Citation GB/T 7714 | Liu, Jianguo,Song, Yanpei,Wu, Xiang,et al. N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source[J]. ACS OMEGA,2021,6(35):22504-22513. |
APA | Liu, Jianguo,Song, Yanpei,Wu, Xiang,&Ma, Longlong.(2021).N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source.ACS OMEGA,6(35),22504-22513. |
MLA | Liu, Jianguo,et al."N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source".ACS OMEGA 6.35(2021):22504-22513. |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment