Knowledge Management System Of Guangzhou Institute of Energy Conversion, CAS
A review on biomass-derived levulinic acid for application in drug synthesis | |
Zhang, Mingyue1,2; Wang, Nan1,3; Liu, Jianguo1,2; Wang, Chenguang1,2; Xu, Ying1,2; Ma, Longlong1,2 | |
2021-06-10 | |
发表期刊 | CRITICAL REVIEWS IN BIOTECHNOLOGY |
ISSN | 0738-8551 |
页码 | 34 |
通讯作者 | Liu, Jianguo(liujg@ms.giec.ac.cn) ; Ma, Longlong(mall@ms.giec.ac.cn) |
摘要 | Levulinic acid (LEV) has been identified as a key building block chemical produced entirely from biomass. Its derivatives can be used to synthesize a variety of value-added chemicals, such as 2-butanone, 2-methyltetrahydrofuran, and so on. LEV has carbonyl and carboxyl functional groups, which makes it flexible, diverse, and unique during drug synthesis. It also reduces the cost of drug synthesis and makes the reaction cleaner and, not the least, has untapped potential in the field of medicine. This article reviews the application of LEV in cancer treatment, medical materials, and other medical fields. Overall, LEV can be used in the following ways: (1) Used as a raw material to directly synthesize drugs; (2) Used to synthesize related derivatives, which can be more specifically used in drug synthesis, and derivatives can achieve the corresponding release of drugs, such as paclitaxel (PTX)- LEV, polymer-betulinic acid (BA)-LEV after amidation; (3) It can modify chemical reagents or act as linkers to connect pharmaceutical reagents with carriers to form pharmaceutical intermediates, a pharmaceutical intermediate skeleton, and so on. (4) It can acylate and esterify to form: acetylpropionate and levulinyl, the indole, pyridazine, and other medicinally active functional groups can be synthesized by a long chain, which can reduce the cost of drug synthesis and simplify the tedious synthesis steps. (5) To form the protective group of levulinic acid, the hydroxyl or carboxyl position is first protected, and then the protective group is removed after the corresponding reaction, in order to participate in drug synthesis. |
关键词 | Biomass levulinic acid drug linkers medicinal materials reducing cost |
DOI | 10.1080/07388551.2021.1939261 |
关键词[WOS] | ONE-POT SYNTHESIS ; 5-AMINOLEVULINIC ACID ; BIOLOGICAL EVALUATION ; DERIVATIVES ; DELIVERY ; POLYMER ; DESIGN ; NANOPARTICLES ; INHIBITORS ; DOCETAXEL |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Key R&D Program of China[2018YFB1501500] ; National Natural Science Foundation of China[51976225] ; DNL Cooperation Fund ; CAS[DNL201916] |
WOS研究方向 | Biotechnology & Applied Microbiology |
项目资助者 | National Key R&D Program of China ; National Natural Science Foundation of China ; DNL Cooperation Fund ; CAS |
WOS类目 | Biotechnology & Applied Microbiology |
WOS记录号 | WOS:000671727500001 |
出版者 | TAYLOR & FRANCIS LTD |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.giec.ac.cn/handle/344007/33461 |
专题 | 中国科学院广州能源研究所 |
通讯作者 | Liu, Jianguo; Ma, Longlong |
作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Energy Convers, Key Lab Renewable Energy, Guangzhou 510640, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Tianjin Univ, Sch Environm Sci & Engn, Tianjin, Peoples R China |
第一作者单位 | 中国科学院广州能源研究所 |
推荐引用方式 GB/T 7714 | Zhang, Mingyue,Wang, Nan,Liu, Jianguo,et al. A review on biomass-derived levulinic acid for application in drug synthesis[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2021:34. |
APA | Zhang, Mingyue,Wang, Nan,Liu, Jianguo,Wang, Chenguang,Xu, Ying,&Ma, Longlong.(2021).A review on biomass-derived levulinic acid for application in drug synthesis.CRITICAL REVIEWS IN BIOTECHNOLOGY,34. |
MLA | Zhang, Mingyue,et al."A review on biomass-derived levulinic acid for application in drug synthesis".CRITICAL REVIEWS IN BIOTECHNOLOGY (2021):34. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论