Knowledge Management System Of Guangzhou Institute of Energy Conversion, CAS
| The effect of enzyme loading, alcohol/acid ratio and temperature on the enzymatic esterification of levulinic acid with methanol for methyl levulinate production: a kinetic study | |
| Song, Miaojia1,3; Di, Xiaohui2; Zhang, Yu1; Sun, Yongming1; Wang, Zhongming1; Yuan, Zhenhong1; Guo, Ying1 | |
| 2021-05-04 | |
| Source Publication | RSC ADVANCES
 |
| Volume | 11Issue:25Pages:15054-15059 |
| Corresponding Author | Zhang, Yu(zhangyu@ms.giec.ac.cn) |
| Abstract | As an important bio-based chemical, methyl levulinate (ML) can be produced via enzymatic esterification of levulinic acid with methanol. A kinetic model is developed in this work based on the law of mass action and reaction reversibility, to investigate the effect of enzyme loading, alcohol/acid ratio and temperature on ML yield. Data analysis shows that newly developed binary regression is apparently more persuasive than the commonly used unitary regression. Kinetic study reveals: (1) rate constants of esterification/hydrolysis increase with increasing enzyme loading, while their ratio (equilibrium constant) remains invariant. (2) Methanol has no toxicity towards lipase, and hence, neither the rate constants of esterification/hydrolysis nor the equilibrium constant are affected by alcohol/acid ratio. (3) Both rate constants of esterification/hydrolysis and the equilibrium constant increase with temperature elevation, and their relationships agree with Arrhenius equation and Van't Hoff equation, respectively. (4) The esterification is endothermic and spontaneous. In total, the application of binary regression analysis for the developed model to study the enzymatic esterification kinetics is quite successful. |
| DOI | 10.1039/d1ra01780b |
| WOS Keyword | LIPASE-CATALYZED ESTERIFICATION ; CANDIDA-ANTARCTICA ; IMMOBILIZATION ; RESOLUTION |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[21978288] ; China Scholarship Council[202008440326] |
| WOS Research Area | Chemistry |
| Funding Organization | National Natural Science Foundation of China ; China Scholarship Council |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000648718400019 |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.giec.ac.cn/handle/344007/33162 |
| Corresponding Author | Zhang, Yu |
| Affiliation | 1.Chinese Acad Sci, Guangzhou Inst Energy Convers, CAS Key Lab Renewable Energy, Guangdong Prov Key Lab New & Renewable Energy Res, Guangzhou 510640, Peoples R China 2.Univ Strasbourg, CNRS UMR 7177, Strasbourg Inst Chem, Lab Synth Organ React & Catalysis, F-67000 Strasbourg, France 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Song, Miaojia,Di, Xiaohui,Zhang, Yu,et al. The effect of enzyme loading, alcohol/acid ratio and temperature on the enzymatic esterification of levulinic acid with methanol for methyl levulinate production: a kinetic study[J]. RSC ADVANCES,2021,11(25):15054-15059. |
| APA | Song, Miaojia.,Di, Xiaohui.,Zhang, Yu.,Sun, Yongming.,Wang, Zhongming.,...&Guo, Ying.(2021).The effect of enzyme loading, alcohol/acid ratio and temperature on the enzymatic esterification of levulinic acid with methanol for methyl levulinate production: a kinetic study.RSC ADVANCES,11(25),15054-15059. |
| MLA | Song, Miaojia,et al."The effect of enzyme loading, alcohol/acid ratio and temperature on the enzymatic esterification of levulinic acid with methanol for methyl levulinate production: a kinetic study".RSC ADVANCES 11.25(2021):15054-15059. |
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