Double-lipase Catalyzed Synthesis of Kojic Dipalmitate in Organic Solvents

doi:10.1007/s40242-017-7048-3

GIEC OpenIR

	Double-lipase Catalyzed Synthesis of Kojic Dipalmitate in Organic Solvents
	Wang Zhiyuan; Luo Wen; Fu Junying; Li Zhibing; Wang Zhongming; Lu Pengmei
	2017-12-01
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	33 期号:6 页码:903-907
通讯作者	Lu Pengmei(lvpm@ms.giec.ac.cn)
摘要	Kojic dipalmitate(KDP) was synthesized by the way of esterification of palmitic and kojic acids in organic solvent, with double-lipase as the biocatalyst. Four commercially available lipases(Amano PS, Novozym 435, Lipozyme TL IM and Lipozyme RM IM) were used to group six double-lipase combinations. These combinations were studied and Amano PS-Novozym 435 was found to have the best efficiency and was selected for optimizing the reaction conditions. The optimal reaction conditions were as follows. The mass ratio of Amano PS to Novozyme 435 was 1:1.5, with stiffing speed of 500 r/min, substrates molar ratio of 1:2, 50 degrees C, 5%(mass fraction) catalyst dosage of kojic acid quantity and using acetone as co-solvent. Under these conditions, the diesterification of C5 and C7 hydroxyl groups of kojic acid molecule could be well catalyzed by double-lipase and realize a high KDP yield of 85%.
关键词	Kojic acid Palmitic acid Kojic dipalmitate Double-lipase catalysis Diesterification
DOI	10.1007/s40242-017-7048-3
关键词[WOS]	ACID ; PRODUCTS
收录类别	SCI
语种	英语
资助项目	Special Funds of Applied Science and Technology Research of Guangdong Province, China[2015B020241002] ; Scientific and Technological Project of Guangdong Province, China[2016A010104008]
WOS研究方向	Chemistry
项目资助者	Special Funds of Applied Science and Technology Research of Guangdong Province, China ; Scientific and Technological Project of Guangdong Province, China
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000426019100009
出版者	HIGHER EDUCATION PRESS
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.giec.ac.cn/handle/344007/23538
专题	中国科学院广州能源研究所
通讯作者	Lu Pengmei
作者单位	Chinese Acad Sci, Key Lab Renewable Energy, Guangzhou Inst Energy Convers, Guangdong Key Lab New & Renewable Energy Res & De, Guangzhou 510640, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Wang Zhiyuan,Luo Wen,Fu Junying,et al. Double-lipase Catalyzed Synthesis of Kojic Dipalmitate in Organic Solvents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2017,33(6):903-907.
APA	Wang Zhiyuan,Luo Wen,Fu Junying,Li Zhibing,Wang Zhongming,&Lu Pengmei.(2017).Double-lipase Catalyzed Synthesis of Kojic Dipalmitate in Organic Solvents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,33(6),903-907.
MLA	Wang Zhiyuan,et al."Double-lipase Catalyzed Synthesis of Kojic Dipalmitate in Organic Solvents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 33.6(2017):903-907.