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Artificial Intelligence Techniques to Optimize the EDC/NHS-Mediated Immobilization of Cellulase on Eudragit L-100
Zhang, Yu; Xu, Jing-Liang1; Yuan, Zhen-Hong; Qi, Wei; Liu, Yun-Yun; He, Min-Chao
2012-07-01
发表期刊INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号13期号:7页码:7952-7962
摘要

Two artificial intelligence techniques, namely artificial neural network (ANN) and genetic algorithm (GA) were combined to be used as a tool for optimizing the covalent immobilization of cellulase on a smart polymer, Eudragit L-100. 1-Ethyl-3-(3-dimethyllaminopropyl) carbodiimide (EDC) concentration, N-hydroxysuccinimide (NHS) concentration and coupling time were taken as independent variables, and immobilization efficiency was taken as the response. The data of the central composite design were used to train ANN by back-propagation algorithm, and the result showed that the trained ANN fitted the data accurately (correlation coefficient R-2 = 0.99). Then a maximum immobilization efficiency of 88.76% was searched by genetic algorithm at a EDC concentration of 0.44%, NHS concentration of 0.37% and a coupling time of 2.22 h, where the experimental value was 87.97 +/- 6.45%. The application of ANN based optimization by GA is quite successful.

文章类型Article
关键词Immobilized Enzyme Cellulase Artificial Intelligence Based Optimization Smart Biocatalyst Carbodiimide Coupling
WOS标题词Science & Technology ; Physical Sciences
DOI10.3390/ijms13077952
研究领域[WOS]Chemistry
关键词[WOS]RESPONSE-SURFACE METHODOLOGY ; NEURAL-NETWORK ; GENETIC ALGORITHM ; HYDROLYSIS ; RSM ; PERFORMANCE ; ADIPATE ; DESIGN ; ANN
收录类别SCI
语种英语
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000306239200006
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.giec.ac.cn/handle/344007/10193
专题中国科学院广州能源研究所
作者单位1.Chinese Acad Sci, Key Lab Renewable Energy & Gas Hydrate, Guangzhou 510640, Guangdong, Peoples R China
2.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangzhou 510640, Guangdong, Peoples R China
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Zhang, Yu,Xu, Jing-Liang,Yuan, Zhen-Hong,et al. Artificial Intelligence Techniques to Optimize the EDC/NHS-Mediated Immobilization of Cellulase on Eudragit L-100[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2012,13(7):7952-7962.
APA Zhang, Yu,Xu, Jing-Liang,Yuan, Zhen-Hong,Qi, Wei,Liu, Yun-Yun,&He, Min-Chao.(2012).Artificial Intelligence Techniques to Optimize the EDC/NHS-Mediated Immobilization of Cellulase on Eudragit L-100.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,13(7),7952-7962.
MLA Zhang, Yu,et al."Artificial Intelligence Techniques to Optimize the EDC/NHS-Mediated Immobilization of Cellulase on Eudragit L-100".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13.7(2012):7952-7962.
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