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In vivo detoxification of furfural during lipid production by the oleaginous yeast Trichosporon fermentans
Huang, Chao1,2; Wu, Hong1; Smith, Thomas J.3; Liu, Zong-jun4; Lou, Wen-Yong5; Zong, Min-hua5
2012-09-01
Source PublicationBIOTECHNOLOGY LETTERS
Volume34Issue:9Pages:1637-1642
Abstract

In vivo detoxification of furfural by the oleaginous yeast, Trichosporon fermentans, under lipid-producing (i.e., nitrogen-limited) conditions was evaluated for the first time. During the initial fermentation phase, furfural was rapidly reduced to furfuryl alcohol, which is more toxic to T. fermentans than furfural. Furfuryl alcohol was subsequently oxidized to furoic acid which has low toxicity to T. fermentans and is the end product of the in vivo detoxification of furfural in this organism. These observations explain how T. fermentans can grow and accumulate lipids in medium containing furfural. They also indicate that strategies to minimize the transient production of furfuryl alcohol could further improve the capacity of the strain to produce lipids from furfural-containing lignocellulosic hydrolysates.

SubtypeArticle
KeywordDetoxification Furfural Furfuryl Alcohol Furoic Acid Trichosporon Fermentans
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s10529-012-0948-x
WOS Subject ExtendedBiotechnology & Applied Microbiology
WOS KeywordSACCHAROMYCES-CEREVISIAE ; OIL PRODUCTION ; HYDROLYSATE ; INHIBITORS ; TOLERANCE ; GLUCOSE ; BIOMASS ; GROWTH
Indexed BySCI
Language英语
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000308234400006
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.giec.ac.cn/handle/344007/10136
Collection中国科学院广州能源研究所
Affiliation1.S China Univ Technol, Coll Light Ind & Food Sci, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China
2.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangzhou 510640, Guangdong, Peoples R China
3.Sheffield Hallam Univ, Biomed Res Ctr, Sheffield S1 1WB, S Yorkshire, England
4.S China Univ Technol, Sch Biosci & Bioengn, Guangzhou 510640, Guangdong, Peoples R China
5.S China Univ Technol, Lab Appl Biocatalysis, Coll Light Ind & Food Sci, Guangzhou 510640, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Huang, Chao,Wu, Hong,Smith, Thomas J.,et al. In vivo detoxification of furfural during lipid production by the oleaginous yeast Trichosporon fermentans[J]. BIOTECHNOLOGY LETTERS,2012,34(9):1637-1642.
APA Huang, Chao,Wu, Hong,Smith, Thomas J.,Liu, Zong-jun,Lou, Wen-Yong,&Zong, Min-hua.(2012).In vivo detoxification of furfural during lipid production by the oleaginous yeast Trichosporon fermentans.BIOTECHNOLOGY LETTERS,34(9),1637-1642.
MLA Huang, Chao,et al."In vivo detoxification of furfural during lipid production by the oleaginous yeast Trichosporon fermentans".BIOTECHNOLOGY LETTERS 34.9(2012):1637-1642.
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